TUMOUR HYPOXIA-MEDIATED IMMUNOSUPPRESSION: MECHANISMS AND THERAPEUTIC APPROACHES TO IMPROVE CANCER IMMUNOTHERAPY

Tumour Hypoxia-Mediated Immunosuppression: Mechanisms and Therapeutic Approaches to Improve Cancer Immunotherapy

The magnitude of the host immune response can be regulated by either stimulatory or inhibitory immune checkpoint molecules.Receptor-ligand binding between inhibitory molecules is often exploited by tumours to suppress anti-tumour immune responses.Immune checkpoint inhibitors that block these inhibitory interactions can relieve T-cells from FACE SOA

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Seroprevalence and associated risk factors of Toxoplasma gondii infection among slaughterhouse workers in Yangon Region, Myanmar: A cross-sectional study.

BackgroundToxoplasmosis, having the significant consequences affecting mortality and quality of life, is still prevalent in various places throughout the world.The major gap in surveillance for Toxoplasma gondii infection among high-risk population, slaughterhouse workers, is an obstacle for the effective policies formulation to reduce the burden o

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Is buffer a good proxy for a crowded cell-like environment? A comparative NMR study of calmodulin side-chain dynamics in buffer and E. coli lysate.

Biophysical studies of protein structure and dynamics are typically performed in a highly controlled manner involving only the protein(s) of interest.Comparatively fewer such studies have been carried out in the context of a cellular environment that typically involves many biomolecules, ions and Helicopters metabolites.Recently, solution NMR spect

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